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Journal: mSphere
Article Title: Metabolic changes associated with polysaccharide utilization reduce susceptibility to some β-lactams in Bacteroides thetaiotaomicron
doi: 10.1128/msphere.00103-24
Figure Lengend Snippet: Carbon source modulates the susceptibility of Bth to β-lactams independent of β-lactamase activity. ( A–C ) Percent growth plot for AMX treatment of Bth grown in MM with different carbon sources ( A ), different concentrations of glucose ( B ), and different concentrations of glucose and pectin ( C ). Data are represented as the average percent growth compared with untreated control cultures ± SEM. G = glucose, P = pectin. ( D ) Percent growth plot for Bth grown in MM-glucose or MM-pectin and treated with various β-lactams. Data are represented as the average percent growth compared with untreated control cultures ± SEM. G = glucose, P = pectin, AMX = amoxicillin, AMP = ampicillin, FOX = cefoxitin, FEP = cefepime, CRO = ceftriaxone, MEM = meropenem. ( E and F ) Percent growth plot for AMX plus tazobactam treatment of Bth grown in MM-glucose ( E ) or MM-pectin ( F ). Data are represented as the average percent growth compared with untreated control cultures.
Article Snippet: Amoxicillin, ampicillin sodium salt,
Techniques: Activity Assay, Control